Core Research Areas

Core Research Areas

Largest Virtual Cell Model

Largest Virtual Cell Model

A closed loop from data to prediction

A closed loop from data to prediction

How Does CellAura Work?

How Research Tasks Get Done

1. Ask a Question

1. Ask a Question

Describe your scientific question and goals in natural language

2. Intelligent Understanding

2. Intelligent Understanding

Understand research intent
Break down the task

3. Simulation & Prediction

3. Simulation & Prediction

Call CellOS models
Simulate how the living system responds

4. Result Integration

4. Result Integration

Integrate analysis results
Generate research insights

5. Scientific Discovery

5. Scientific Discovery

Deliver conclusions and recommendations
Guide experimental decisions

CellOS Intelligence Engine:A three-tier model system that drives research forward

01 Foundation Model

01 Foundation Model

CellOS

Pre-trained on large-scale multimodal single-cell data to understand cell states and the language of life.

02 General Perturbation Model

02 General Perturbation Model

CellOS.Pert

Learns how cells respond to diverse perturbations and predicts the resulting state changes and trends.

03 Domain-Specific Custom Models

03 Domain-Specific Custom Models

CellOS.Turbo

Delivers higher-precision prediction and analysis for specific diseases, cell types, and research scenarios.

Immune Cells

Immune Cells

Auralmmune

Tumors & Microenvironment

Tumors & Microenvironment

AuraOnco

Engineered Cells

Engineered Cells

AuraSynth

Drug Discovery & Development

Drug Discovery & Development

AuraDev

More Domain Models

Continuously Expanding

Less Time on Tools, More Time on Science

Before

Researchers adapt to tools

Researchers

Researchers

Python

Python

R

R

Scapy

Scapy

Seurat

Seurat

Cell Ranger

Cell Ranger

Fragmented Tools

Fragmented Tools

Steep Learning Curve

Steep Learning Curve

Low Efficiency

Low Efficiency

High Cost of Trial and Error

High Cost of Trial and Error

Now

Tools adapt to researchers

Scientific Questions

Scientific Questions

CellAura Agent Platform

Multimodal Data

Multimodal Data

Single-cell | Spatial multicellular biology | Wenmo knowledge | Experimental data

Biological Knowledge Base

Biological Knowledge Base

Pathways | Regulatory networks | Cell types | Literature

CellOS Model Engine

Simulate before you experiment.

Cell State Analysis

Cell State Analysis

Perturbation Response Prediction

Perturbation Response Prediction

Experimental Strategy Recommendations

Experimental Strategy Recommendations

Iterative Model–Experiment Loop

Iterative Model–Experiment Loop

Gain insights faster, reduce trial-and-error costs, and accelerate scientific discovery and innovation.

Natural Language Interaction

Natural Language Interaction

Start with a Question
Zero Learning Curve

Autonomous Research Task Orchestration

Autonomous Research Task Orchestration

Automated planning and execution,
so researchers can focus on scientific thinking

Powered by Virtual Cell Models

Powered by Virtual Cell Models

Narrow the experimental search space through simulation,
reducing experimental costs

Closed-Loop Iterative Optimization

Closed-Loop Iterative Optimization

Data and models keep evolving
Results keep accumulating

Core Capabilities

Every research decision is backed by an AI agent and virtual cell models

Bioinformatics Analysis

From raw data to cell states: the agent orchestrates the complete analysis pipeline

Describe your analysis goals in natural language, and the agent automatically plans and invokes quality control, integration, clustering, annotation, differential expression, enrichment, and more—turning raw single-cell data into an interactive cell atlas with structured interpretation. These results can be used on their own to understand your data, or serve as a shared starting point for subsequent virtual perturbation.

Cell type/state annotation and composition interpretation

Cell type/state annotation and composition interpretation

Differential gene expression and pathway enrichment analysis

Differential gene expression and pathway enrichment analysis

Interactive side-by-side review of UMAPs, marker heatmaps, and more

Interactive side-by-side review of UMAPs, marker heatmaps, and more

The agent orchestrates multiple bioinformatics skills per task, with a fully traceable process

The agent orchestrates multiple bioinformatics skills per task, with a fully traceable process

Virtual Perturbation

Lock in the starting cell state and run reproducible gene perturbation simulations

On annotated cell states, specify genes to knock down or knock out, or request perturbation recommendations based on a target phenotype. Our proprietary virtual cell engine produces interpretable predictions of downstream transcriptional and functional effects. Every simulation records its parameters and model version, and conclusions are labeled as hypothesis-grade to inform subsequent study design and wet-lab validation.

Simulate knockdown/knockout (KD/KO) of specified genes

Simulate knockdown/knockout (KD/KO) of specified genes

Intent-driven perturbation recommendations (candidate ranking with mechanistic interpretation)

Intent-driven perturbation recommendations (candidate ranking with mechanistic interpretation)

Differential genes, pathways, and functional impacts presented side by side

Differential genes, pathways, and functional impacts presented side by side

Traceable simulation parameters and engine versions; conclusions are hypothesis-grade, pending validation

Traceable simulation parameters and engine versions; conclusions are hypothesis-grade, pending validation

Model Customization

Integrate vertical models and train on your own data

On top of the general perturbation foundation, plug in vertical models such as Aging-VC and Aging-KG, or launch online training and iteration on your project's own data to produce versioned, uniquely identified domain endpoints. Within a session, the agent calls published models as the scenario requires, so predictions for skin anti-aging and other specialized projects are built on auditable model assets.

Plug in vertical virtual cell models by project (anti-aging first, extensible to other areas)

Plug in vertical virtual cell models by project (anti-aging first, extensible to other areas)

Train or fine-tune online on your own data to improve perturbation performance in your domain

Train or fine-tune online on your own data to improve perturbation performance in your domain

Model IDs and versions that can be called, compared, and audited

Model IDs and versions that can be called, compared, and audited

Domain knowledge enhancement (e.g., Aging-KG), with evidence and inference presented separately

Domain knowledge enhancement (e.g., Aging-KG), with evidence and inference presented separately

Dry–Wet Closed Loop

Platform prediction → offline validation → results fed back, driving the next iteration

Once virtual predictions yield candidates, the system drafts an executable experimental protocol (controls, endpoints, and linked prediction records) and coordinates offline validation with partner labs. When measured data comes back, it is compared item by item against predictions; hypothesis status is written back to project memory and can inform the model and the next round of design.

Experimental protocols linked to platform prediction records

Experimental protocols linked to platform prediction records

Offline task submission, progress tracking, and result collection

Offline task submission, progress tracking, and result collection

Item-by-item comparison of predictions vs. measurements, labeled as supported, inconclusive, or refuted

Item-by-item comparison of predictions vs. measurements, labeled as supported, inconclusive, or refuted

Hypotheses written back and cases archived to inform the model and the next round of decisions

Hypotheses written back and cases archived to inform the model and the next round of decisions

Let the next breakthrough begin with AIVC.